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  2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase

ACC, Acetyl Coenzyme A Carboxylase

Acetyl-CoA Carboxylase

Related Products

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Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.

In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135753
    Sethoxydim
    		Inhibitor
    Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity.
    Sethoxydim
  • HY-161116
    AD-5584
    		Inhibitor
    AD-5584 is an ACSS2 inhibitor with blood-brain permeability. AD-5584 can significantly reduce lipid storage, reduce colony formation, and increase cell death. AD-5584 has antitumor activity.
    AD-5584
  • HY-16943
    Moiramide B
    		Inhibitor 99.24%
    Moiramide B is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of 6 nM. Moiramide B has antibacterial activity.
    Moiramide B
  • HY-147930
    ACC1/2-IN-1
    		Inhibitor
    ACC1/2-IN-1 (compound 4s) is a potent ACC1/2 inhibitor with IC50 values of 98.06 and 29.43 nM for ACC1 and ACC2, respectively. ACC1/2-IN-1 can be used for cancer research.
    ACC1/2-IN-1
  • HY-139134
    S-2E
    		Inhibitor
    S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.
    S-2E
  • HY-123307
    Quizalofop
    		Inhibitor
    Quizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production.
    Quizalofop
  • HY-147376
    hACC2-IN-1
    		Inhibitor
    hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research.
    hACC2-IN-1
  • HY-169009
    (Rac)-Spirotetramat-enol
    (Rac)-Spirotetramat-enol (Compound 8) is a ligand of acetyl-CoA carboxylase that can be used to synthesize PROTAC ADC degrader (HY-169008).
    (Rac)-Spirotetramat-enol
  • HY-147932
    ACC1/2-IN-2
    		Inhibitor
    ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC50 values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research.
    ACC1/2-IN-2
  • HY-161976
    ACC1-IN-2
    		Inhibitor
    ACC1-IN-2 (Compound 16) is an ACC1 inhibitor with an IC50 of 7.3 nM. ACC1-IN-2 can be used in the study of acne.
    ACC1-IN-2
  • HY-16946
    CP-610431
    		Inhibitor
    CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits ACC1 and ACC2 with IC50s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome.
    CP-610431
  • HY-169008
    PROTAC ACC degrader-1
    		Degrader
    PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC50 = 107.8 μg/mL). (Structure Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-10984); Black, linker (HY-W007559).
    PROTAC ACC degrader-1
  • HY-117142
    Quizalofop-P
    		Inhibitor
    Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops.
    Quizalofop-P
  • HY-158246
    QPP-I-6
    		Inhibitor
    QPP-I-6 is an inhibitor for acetyl-coenzyme A carboxylase (ACCase). QPP-I-6 exhibits herbicidal activity through induction of cell membrane permeability.
    QPP-I-6
  • HY-111223R
    Tralkoxydim (Standard)
    		Inhibitor
    Tralkoxydim (Standard) is the analytical standard of Tralkoxydim. This product is intended for research and analytical applications. Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn.
    Tralkoxydim (Standard)
  • HY-117142R
    Quizalofop-P (Standard)
    		Inhibitor
    Quizalofop-P (Standard) is the analytical standard of Quizalofop-P. This product is intended for research and analytical applications. Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops.
    Quizalofop-P (Standard)
  • HY-B1856R
    Haloxyfop (Standard)
    		Inhibitor
    Haloxyfop (Standard) is the analytical standard of Haloxyfop. This product is intended for research and analytical applications. Haloxyfop is an aryloxyphenoxypropionic acid herbicide and is widely used in grass weeds in broad-leaf crops. Haloxyfop inhibits the acetyl coenzyme A carboxylase (EC 6.4.1.2) from corn seedling chloroplasts with an IC50 of 0.5 μM, but has no effect on this enzyme in pea.
    Haloxyfop (Standard)
  • HY-135753R
    Sethoxydim (Standard)
    		Inhibitor
    Sethoxydim (Standard) is the analytical standard of Sethoxydim. This product is intended for research and analytical applications. Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity.
    Sethoxydim (Standard)
  • HY-170931
    AMPK activator 16
    		Activator
    AMPK activator 16 (compound 6) is a AMP-activated protein kinase (AMPK) inhibitor. AMPK activator 16 shows the most efficient interactions with the key residues of AMPK and demonstrates significant activation of AMPK. AMPK activator 16 increases the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) (p-ACC) and phosphorylated raptor (p-raptor), in N2a cells.
    AMPK activator 16
  • HY-B2007R
    Fluazifop-P-butyl (Standard)
    		Inhibitor
    Fluazifop-P-butyl (Standard) is the analytical standard of Fluazifop-P-butyl. This product is intended for research and analytical applications. Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor.
    Fluazifop-P-butyl (Standard)
Cat. No. Product Name / Synonyms Application Reactivity