2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase

ACC, Acetyl Coenzyme A Carboxylase

Acetyl-CoA Carboxylase

Related Products

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Acetyl-CoA carboxylase catalyzes the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis. Acetyl-CoA carboxylase has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer, and other diseases.

In animals, there are two major isoforms of ACCs, ACC1, and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution. The first committed step of fatty acid synthesis (FASyn) is mediated by ACC, which in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks carnitine palmitoyltransferase-1 (CPT-1) function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139134
    S-2E
    		Inhibitor
    S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.
    S-2E
  • HY-123307
    Quizalofop
    		Inhibitor
    Quizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production.
    Quizalofop
  • HY-147376
    hACC2-IN-1
    		Inhibitor
    hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research.
    hACC2-IN-1
  • HY-147932
    ACC1/2-IN-2
    		Inhibitor
    ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC50 values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research.
    ACC1/2-IN-2
  • HY-135753
    Sethoxydim
    		Inhibitor
    Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity.
    Sethoxydim
  • HY-B2007R
    Fluazifop-P-butyl (Standard)
    		Inhibitor
    Fluazifop-P-butyl (Standard) is the analytical standard of Fluazifop-P-butyl. This product is intended for research and analytical applications. Fluazifop-P-butyl, a graminicide from arylophenoxypropionate group, is a acetyl-CoA carboxylase (ACCase) inhibitor.
    Fluazifop-P-butyl (Standard)
  • HY-16946
    CP-610431
    		Inhibitor
    CP-610431 is a reversible, ATP-uncompetitive, isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor. CP-610431 inhibits ACC1 and ACC2 with IC50s of ~50 nM. CP-610431 can be used for the research of metabolic syndrome.
    CP-610431
  • HY-169008
    PROTAC ACC degrader-1
    		Degrader
    PROTAC ACC degrader-1 (Compound 9b) is a Acetyl-CoA Carboxylase degrader. PROTAC ACC degrader-1 exhibits superior potency against Aphis craccivora (IC50 = 107.8 μg/mL). (Srtucture Note: Pink, Target protein ligand (HY-169009); Blue, E3 ligand (HY-10984); Black, linker (HY-W007559).
    PROTAC ACC degrader-1
  • HY-117142
    Quizalofop-P
    		Inhibitor
    Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops.
    Quizalofop-P
  • HY-158246
    QPP-I-6
    		Inhibitor
    QPP-I-6 is an inhibitor for acetyl-coenzyme A carboxylase (ACCase). QPP-I-6 exhibits herbicidal activity through induction of cell membrane permeability.
    QPP-I-6
  • HY-111223R
    Tralkoxydim (Standard)
    		Inhibitor
    Tralkoxydim (Standard) is the analytical standard of Tralkoxydim. This product is intended for research and analytical applications. Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn.
    Tralkoxydim (Standard)
  • HY-117142R
    Quizalofop-P (Standard)
    		Inhibitor
    Quizalofop-P (Standard) is the analytical standard of Quizalofop-P. This product is intended for research and analytical applications. Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops.
    Quizalofop-P (Standard)
  • HY-135753R
    Sethoxydim (Standard)
    		Inhibitor
    Sethoxydim (Standard) is the analytical standard of Sethoxydim. This product is intended for research and analytical applications. Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity.
    Sethoxydim (Standard)
  • HY-111223
    Tralkoxydim
    		Inhibitor
    Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn.
    Tralkoxydim
  • HY-117262R
    Propaquizafop (Standard)
    		Inhibitor
    Propaquizafop (Standard) is the analytical standard of Propaquizafop. This product is intended for research and analytical applications. Propaquizafop is a phenoxyisopropionic acid herbicide and an acetyl-coA carboxylase inhibitor.
    Propaquizafop (Standard)
Cat. No. Product Name / Synonyms Application Reactivity